一、个人简介
侯路宽，男，汉族，山东菏泽人，博士，中共党员，副教授，硕士生导师。
2018年毕业于中国海洋大学，获得博士学位，导师李文利教授。2019-2021年，在美国南卡莱罗纳大学从事博士后研究工作。2022年加入维多利亚老品牌76696vic维多利亚老品牌76696vic。现任《中国抗生素杂志》青年编委。
二、研究领域
1. 基因组信息指导下的微生物活性天然产物的定向发掘；
2. 微生物活性天然产物的合成生物学研究；
三、科研项目
1. 国家自然科学基金青年科学基金项目，30万，主持
2. 陕西省自然科学基金青年项目，5万，主持
3. 维多利亚老品牌76696vic博士科研启动基金，20万，主持
4. 国家自然科学基金委员会, 联合基金项目，257万，骨干参与，到账经费10万
5. 国家自然科学基金委员会, 联合基金项目，286万，参与
6. 地市级纵向协作项目，骨干参与，到账经费15万
四、开设课程
为本科生讲授《微生物学》、《微生物学实验》、《无机及分析化学》、《工程化学》和《天然产物化学实验》等课程
五、主要科研成果
1. Hou LK, Wang SY, Zhang YH, Yang X, Chen ZH, Gao YX, Li WL*. Targeted discovery of diterpene compounds ostamycins with anti-influenza A viral activity from a deepsea-derived Streptomyces strain. Bioorganic Chemistry , 2025: 108268.
2. Ma GY#, Hou LK#, Guo JH, Sun JC, Nong QN, Wang YF, Hu SW, Zhao WJ, Tan J, Liu XF, Guo Y, Zhang BJ, Wang HL, Wang SY, Li XQ, Cao W*. The structures of two polysaccharides from Fructus Corni and their protective effect on insulin resistance. Carbohydrate Polymers , 2025: 123290.
3. Pulliam C#, Hou LK#, Xue D, Xu MM, Holandez-Lopez K, Li J*. A Bacterial Sulfotransferase Catalyzes an UnusualDi-Sulfation in Natural Products Biosynthesis. ChemBioChem , 2025: 2500024.
4. Hou LK#, Yang X#, Wang SY, Li WL*.New phenazines from Taibai mountain-derived Streptomyces xanthophaeus A54. Natural Product Research , 2025 (Accepted).
5. Wu XT#, Hou LK#, Zhang HL, Ma Y, Wang JF, Cai MW*, Tang XY*. Identification of 3-ketocapnine reductase activity within the human microbiota. Mlife , 2024, 3(2): 307–316.
6. Hou LK#, Tian HY#, Wang L, Ferris ZE, Wang JF, Cai MW, Older EA, RajaMRK, Xue D, Sun WY, Nagarkatti P, Nagarkatti M, ChenHX, Fan DP, Tang XY* and Li J*. Identification and biosynthesis of pro-inflammatory sulfonolipids from an opportunistic pathogen Chryseobacterium gleum . ACS Chemical Biology, 2022, 17(5): 1197–1206.
7. Hou LK#, Li Y#, Wu QH, Li MY, Older EA, Tang XY, Nagarkatti P, Nagarkatti M, Li LJ, Fan DP, Bugni T, Shang Z*, Li J*. Discovery of anti-infective adipostatins through bioactivity-guided isolation and heterologous expression of a type Ⅲ polyketide synthase. Bioorganic Chemistry , 2021, 112: 104925.
8. Hou LK, Liu ZZ, Yu DQ, Li HY*, Ju JH, Li WL*. Targeted discovery of novel polycyclic tetramate macrolactams from deepsea-derived Streptomyces somaliensis SCSIO ZH66. Bioorganic Chemistry , 2020, 101: 103954.
9. Hou LK, Huang HM, Li HY, Wang SY, Ju JH, Li WL*. Overexpression of a type III PKS gene affording novel violapyrones with enhanced anti-influenza A virus activity. Microbial Cell Factories , 2018, 17: 1–11.
10. Hou LK, Wang SY, Huang HM, Li HY, Li WL*. Generation of methylated violapyrones with improved anti-influenza A virus activity by heterologous expression of a type III PKS gene in a marine Streptomyces strain. Bioorganic & Medicinal Chemistry Letters , 2018, 28(17): 2865–2868.
11. Han X#, Hou LK#, Hou J, Zhang YY, Li HY*, Li WL*. Heterologous expression of a VioA variant activates cryptic compounds in marine-derived Brevibacterium sp. Marine Drugs , 2018, 16(6): 191.
12. 侯路宽, 李花月, 李文利*. 隐性次级代谢产物生物合成基因簇的激活及天然产物定向发现. 微生物学报 , 2017, 57(11): 1722–1734.
13. Xue D,# Wu QH,# Hou LK, Pulliam C, Xu MM, Madden MD, Madu J, Li Y, Liu SF, Fan DP, Bugni TS, Wang T, Li J.* Discovery and Biosynthetic Interrogation of a Cobalt-Containing Terpene-Polyketide-Nonribosomal Peptide Tribrid with Anticoronavirus Activity, Journal of the American Chemical Society, 2025, 147, 38951−38957.
14. Xue D, Zou HB, Qiu YP, Lv W, Madden MD, Xu MM, Lian XY, Pulliam C, Older EA, Hou LK, Campbell A, Rond TD, Awakawa T, Yuan CH, Moore BS, Li J. Discovery of acylsulfenic acid-featuring natural product sulfenicin and characterization of its biosynthesis. Nature Chemistry, 2025: 1-9.
15. Xue D#, Older EA#, Zhong Z#, Shang Z, Chen NZ, Dittenhauser N, Hou LK, Walla MD, Dong SH, Tang XY, Nagarkatti P, Nagarkatti M, Li YX*, Li J*. Correlational networking guides the discovery of unclustered lanthipeptide protease-encoding genes. Nature Communications , 2022, 13(1): 1647.
16. Zhang YY, Zhao YN, Wang NN, Wang HR, Yang P, Zhai YJ, Hou LK, Li WL*. Characterization of the Biosynthesis of Pimprinine-Type Indolyloxazoles Unravels an Unusual D-Configurational Substrate Metabolic Streamline. Journal of the American Chemical Society , 2025. https://doi.org/10.1021/jacs.5c01705.
17. 授权专利: 李文利，侯路宽，李花月，黄会明，吡喃酮类化合物及制备方法、用途。2020. 04. 28，中国，ZL201810115669. 3.
六、联系方式
通讯地址：陕西杨凌西农路22号，维多利亚老品牌76696vic维多利亚老品牌76696vic
邮编：712100
邮箱：houlukuan@nwafu.edu.cn